Below are supplemental abstracts and references of research that support the conclusions on the treatment for Aphthous Stomatitis

. Diet and Nutrition References

Food allergies

"Celiac disease: could you be missing this common problem." Consultant. Dec,2004:1757-1759.

Catassi C, et al. "High prevalence of undiagnosed celiac disease in 5,280 Italian students screened by antigliadin antibodies." ACTA Pediatrica. 1995;84:672-676.

O'Farrelly C, et al. "Gliadin antibodies identify gluten-sensitive oral ulceration in the absence of villous atrophy." J Oral Pathol Med. 1991;20:476-478.

Nolan A, et al. "Recurrent aphthous ulceration and food sensitivity." J Oral Pathol Med. 1991;20:473-475.

Wright A, et al. "Food allergy or intolerance in severe recurrent aphthous ulceration of the mouth." Br Med J. 1986;292:1237-1238.

Blacklow RS. Signs and Symptoms. 6th ed. JB Lippincott Co. NY, NY; 1983:133.

Little JW. "Food allergens and basophil histamine release in recurrent aphthous stomatitis." Oral Surgery. 1982;54:388-95.

Wray D. "Gluten-sensitive recurrent aphthous stomatitis." Dig Dis Sci. 1981;26:73740.

Hay KD, Reade PC. "The use of an elimination diet in the treatment of recurrent aphthous ulceration of the oral cavity." Oral Surg. 1981;57:504-7.

Wilson CWM. "Food sensitivities, taste changes, aphthous ulcers and atopic symptoms in allergic disease." Ann Allergy. 1980;44:302-7.

Ferguson MM, et al "Coeliac disease associated with recurrent aphthae." Gut. 1980;21:223-6.

Walker DM, et al. "Gluten hypersensitivity in recurrent aphthous ulceration." J Dent Res. 1979;58(Special Issue C):1271.

Wray DW, et al. "Nutritional deficiencies in recurrent aphthae." J Oral Path. 1978;7:418-23.

Rays RA, et al. "Immunoglobulin-bearing lymphocytes and polymorphonuclear leukocytes in recurrent aphthous ulcers in man." Arch Oral Biol. 1977;22:147-53.

Rogers RS. "Recurrent aphthous stomatitis: clinical characteristics and evidence for an immunpathogenesis." J Invest Dermatol. 1977;69:499.

Fergirsom, et al. "Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration." Br Med J. 1975;1:11-3.

Thomas HC, et al. "Food antibodies in oral disease: A study of serum antibodies to food proteins in aphthous ulceration and other oral diseases." J Clin Path. 1973;26:3714.

Ship, et al. "Recurrent aphthous ulcers." Am J Med. 1962;32:3243.

Vitamin and Mineral References

Vitamin C

Marz RB. Medical Nutrition from Marz, 2nd ed. Omni Press; Portland, OR; 1997:367.

Pizzorno JE, Murray MT. Textbook of Natural Medicine, Vol II. Bastyr Univ Publications; Seattle,WA; 1993;VI:1-2.

Vitamin B12

Wray D, et al. "Recurrent aphthae: treatment with vitamin B12, folic acid, and iron." Br Med J. 1975;2:490-493.

Vitamin B12, Folate and Iron Deficiency

Field EA, et al. "Clinical and haematological assessment of children with recurrent aphthous ulceration." Br Dent J. 1987;163:19-22.

Wray D, et al. "Nutritional defciencies in recurrent aphthae." J Oral Pathol. 1978;7(6):418-423.

Wray D, et al. "Recurrent aphthae: treatment with vitamin B12, folic acid and iron." Br Med J. 1975;2:490-493.


Rieber WA. "Aphthous Ulcers: Zinc." Cortlandt Forum. 1991;April;101:38-47.

Wray D. "A double blind trial of systemic zinc sulfate in recurrent aphthous stomatitis." Oral Surg. 1982;53:469.

Merchant HW, et al. "Zinc sulfate supplementation for treatment of recurring oral ulcers." South Med J. 1977;70:559.

Supplement References


Ohnishi E, Bannai H. "Quercetin potentiates tumor necrosis factor-induced antiviral activity." Antiviral Res. 1993;22:327-331.

Pearce FL, et al. "Mucosal mast cells III: Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells." J Allergy Clin Immunol. 1984;73:819-23.

Busse WW, et al. "Flavonoid modulation of human neutrophil function." J Allergy Clin Immnunol. 1984;73:801-9.


Balch JF, et al. Prescription for Nutritional Healing, 2nd ed. Avery Publishing; NY, NY; 1997:187.

Lactobacilius Acidophilus

James APR. "Common dermatologic disorders." CIBA Clin Symposia. 1967;19(2):38-64.

Botanical References

Calendula officinalis, Symphytum officinale, Commiphora molmol, Berberis vulgaris, Hamamelis virginiana, Baptisia tintoria, Zanthoxylum clava-herculis, Sanguinaria canadensia, Thuja plicata or occidentalis, Melaleuca alternifolia

Mitchell WA. Plant Medicine. Preparatory Manuscript; Seattle, WA; 2000.

Tilgner S. Herbal Medicine-From the Heart of the Earth. Wise Acres Press, Inc.; Creswell, OR; 1999.

Ogletree RL, Rischer RG. Physician's and Pharmacist's Guide to the Top 10 Scientifically Proven Natural Products. Natural Source Digest; 2nd Ed. Brandon, MS; 1997.

Chevallier A. The Encyclopedia of Medicinal Plants. DK Publishing; New York, NY; 1996:55.

Murray MT. The Healing Power of Herbs. 2nd Ed. Prima Publishing; Rocklin, CA; 1995.

Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy; Botanical Vol. II. Eclectic Medical Publications; Sandy, OR; 1994.

Felter HW. The Eclectic Materia Medica, Pharmacology and Therapeutics, Botanical Vol. 1. Eclectic Medical Publications; Sandy, OR; 1994.

Scalzo R. Naturopathic Handbook of Herbal Formulas. 3rd Ed. Kivaki Press; Durango, CO; 1994.

Ody P. The Complete Medicinal Herbal. Dorling Kindersley; New York, NY; 1993.

Stansbury JE. Botanical Medicines Acting on the Respiratory System. Preparatory Manuscript; Battleground, WA; 1992.

Stansbury JE. Pharmacognosy for the Herbal Practitioner. Preparatory Manuscript; Battleground, WA; 1992.

Thomas L. 10 Essential Herbs. Hohm Press; Prescott, AZ; 1992.

Weiss RF. Herbal Medicine. Beaconsfield Publishers LTD; Beaconsfield, England; 1991.

Hoffman, D. The New Holistic Herbal. Element Inc; Rockport, MA; 1991.

Mabey R, et al. The New Age Herbalist. Collier Books, Macmillan Publishing Company; New York, NY; 1988. England;1988.

Tyler VE, et al. Pharmacognosy. 9th Ed. Lea & Febiger; Philadelphia, PA; 1988.

Wren RC. Potter's New Cyclopaedia of Botanical Drugs and Preparations. The C.W. Daniel Company Limited; Essex; 1988

Carr A, et al. Rodale's Illustrated Encyclopedia of Herbs. Rodale Press; Emmaus, PA; 1987.

Mowrey DB. The Scientific Validation of Herbal Medicine. Keats Publishing, Inc.; New Canaan, CT; 1986.

Beyer P. The Master Book of Herbalism. Phoenix Publishing; Custer, WA; 1984.

Goodenough J. Dr. Goodenough's Home Cures & Herbal Remedies. Avenel Books; New York, NY; 1982.

Millspaugh CF. American Medicinal Plants. Dover Publications, Inc.; New York, NY; 1974.

Grieve M. A Modern Herbal. Vol. I & II; Dover Publications, Inc.; New York, NY; 1971.

Homeopathy References

Morrison R.Desktop Guide to Keynotes and Confirmatory Symptoms.Hahnemann Clinic Publishing; Albany, CA; 1993.

Murphy R.Homeopathic Medical Repertory.Hahnemann Academy of North America; Pagosa Springs, CO; 1993.

Phatak SR. A Concise Repertory of Homoeopathic Medicines. B. Jain Publishers Pvt. Ltd.; New Delhi, India; 1992.

Kruzel T. The Homeopathic Emergency Guide.North Atlantic Books; Berkeley, CA; 1992.

Kent JT. Repertory of the Homeopathic Materia Medica.B. Jain Publishers (P) LTD; New Delhi, India; 1991.

Boericke W. Materia Medica with Repertory, 9th Ed..Boericke & Tafel, Inc.; Santa Rosa, CA; 1927.

Other Treatment References

Mercury Amalgams

Kasuistiken D. "Amalgam allergy with stomatitis and perioral eczema. Three case reports." Allergy. 1990;13(10):S389-391.

Relaxation/Imagery Training

Andrews VH, Hall HR. "The effects of relaxation/imagery training on recurrent aphthous stomatitis: a preliminary study." Psychosom Med. September/October,1990;52(5):526-535.

Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).