Below are supplemental abstracts and references of research that support the conclusions on the treatment for Bipolar Disorder

. Diet and Nutrition References


Food Allergy

Rix KJ, et al. "Food antibodies in acute psychoses." Psychol Med. 1985;15(2):347-54

Davies S, Stewart A. Nutritional Medicine, London, Pan Books. 1987:403.


Caffeine

Tondo L, et al. "Course of seasonal bipolar disorder influenced by caffeine." J Affective Disorder. 1991;22:249-251.


Alkalizing Agents

Castrogiovanni P, Pieraccini F. "Dietary interferences with lithium therapy." Eur Psychiatr. 1996;11:53-54.


Vitamin and Mineral References


Vitamin B6

Bernstein AL. "Vitamin B6 in clinical neurology." Annal NY Acad Sci. 1990,585:250-60.

Green AR, Aronson JK. "The pharmacokinetics of oral L-tryptophan: effects of dose and concomitant pyridoxine, allopurinol or nicotinamide administration." Adv Biol Psychiatr. 1983;10:67-81.


Vitamin B12

Edwin E, et al. "Vitamin B12 hypovitaminosis in mental diseases." Acta Med Scand. 1965;177:689-99.


Vitamin B12 and Folate

Popper CW. "Do vitamins or minerals (apart from lithium) have mood-stabilizing effects?" J Clin Psychiatry. December,2001;62(12):933-944.

Bell IR et al. "Vitamin B12 and folate status in acute geropsychiatric inpatients: affective and cognitive characteristics of a vitamin nondeficient population." Biol Psychiatr. Jan15,1990;27(2):125-37.

Kallstrom B, et al. "Vitamin B12 and folate concentrations in mental patients." Acta Psychiatr Scand. 1969;45:137-52.

Hunter R, et al. "Serum B12 and folate concentration in mental patients." Br J Psychiatr. 1967;113:1291-5.


Vitamin C

Schorah CJ, et al. "Vitamin C concentrations in patients in a psychiatric hospital." Hum Nutr Clin Nutr. 1983;37C:447-52.

Milner G. "Ascorbic acid in chronic psychiatric patients: a controlled trial." Br J Psychiatr. 1963;109:294-99.

Rimland B. "Plasma vitamin C in the prevention and treatment of autism." Autism Res Rev Intl. 1998;12(2):3.


Folate

Muskiet FAJ, Kemperman RFJ. "Folate and long-chain polyunsaturated fatty acids in psychiatric disease." J Nutr Biochem. 2006;17(11):717-27.

Taylor MJ, Geddes J. "Folic acid as ultimate in disease prevention: Folate also improves mental health." BMJ. March27,2004;328:768.

Arinami T, et al. "Methylenetetrahydrofolate reductase variant and schizophrenia/depression." Am J Med Genet (Neuropsychiatr Genet). 1997;74:526-528.

Anderson DN, Abou-Saleh MT. "Tetrahydrobiopterin, folate and depression: a modified amine hypothesis." Human Psychopharmacol. 1995;10:1-5.

Lee S, et al. "Folate concentration in Chinese psychiatric patients on long term lithium treatment." J Affective Disorder. 1992;24:265-270.

Carney MP. "Vitamins and mental health." Br J Hosp Med. Editorial,October21-November3,1992;48(8).

Coppen A, et al. "Depression and tetrahydrobiopterin: the folate connection." J Affective Disorder. 1989;16(2-3):103-07.

Coppen A, Abou-Saleh MT. "Plasma folate and affective morbidity during long-term lithium therapy." Br J Psychiatr. 1982;141:87-89.

Lipton M, et al. "Vitamins, megavitamin therapy and the nervous system." Nutrition and the Brain New York, Raven Press. 1979;183-264.


Phosphatidyl Choline

Cohen BM, et al. "Lecithin in the treatment of mania: double-blind, placebo-controlled trials." Am J Psychiatr. 1982;139:1162-64.

Cohen BM, et al. "Lecithin in mania: a preliminary report." Am J Psychiatr. 1980;137:242-3.


Lithium

Belmaker RH, et al. "How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory." Ann Rev Med. 1996;47:47-56.

Jefferson JW. "Lithium: the present and the future." J Clin Psychiatry. August,1990;51(suppl 8):4-8.

Fierro AA. "Natural low dose lithium supplementation in manic_depressive disease." Nutr Perspectives. January,1988;10-11.


Potassium

Bhaskara RT. Clin Psychiatr News. 1990;18(10):3.


Supplement References


Omega-3 Fatty Acids

Wozniak J, et al. "Omega-3 fatty acid monotherapy for pediatric bipolar disorder: A prospective open-label trial." Eur Neuropsychopharmacol. 2007;17(6-7):440-7.

Parker G, et al. "Omega-3 fatty acids and mood disorders." Am J Psychiatry. 2006;163(6):969-78.

Frangou S, et al. "Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomized double-blind placebo-controlled study." Br J Psychiatry. 2006;188:46-50.

Hirashima F, et al. "Omega-3 fatty acid treatment and T2 whole brain relaxation times in bipolar disorder." Am J Psychiatry. Oct,2004;161(10):1922-1924.

Hakkarainen R, et al. "Is low dietary intake of omega-3 fatty acids associated with depression?" Am J Psychiatry. March,2004;161(3):567-569.

Family Practice News. "Depression linked to lower omega-3 fatty acid levels." April15,2004:54.

Leaf A. "The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain." Lipids. 2001;36(Suppl):S107-S110.

Stoll AL. "Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial." Arch Gen Psychiatr. May,1999;56(5):407-12.

Rudin DO. "The major psychoses and neuroses as omega-3 essential fatty acid deciciency syndrome: substrate pellagra." Biol Psychiatr. 1981;16(9):837-50.


Omega-6 Fatty Acids

Lieb J. "Linoleic acid in the treatment of lithium toxicity and familial tremor." Prostaglandins Med. 1980;4:275-79.


L-Phenylalanine

Sabelli HC, et al. "Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements." J Clin Psychiatry. February,1986;47(2): 66-70.

Simonson M. "L-phenylalanine." J Clin Psychiatry. August,1985;46(8):355.

Sabelli HC, et al. "Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements." J Clin Psychiatr. 1983;47(2):66-70.


Tryptophan

Bellivier F, et al. "Association between the tryptophan hydroxylase gene and manic-depressive illness." Arch Gen Psychiatr. 1998;55:33-37.

Cassidy F, et al. "Tryptophan depletion in recently manic patients treated with lithium." Biol Psychiatr. 1998;43:230-232.

Benkelfat C, et al. "Tryptophan depletion in stable lithium-treated patients with bipolar disorder in remission." Arch Gen Psychiatry. February,1995;52:154-155.

Sandyk R. "L-tryptophan in neuropsychiatric disorders: a review," Intl J Neurosci. 1992;67:127-144.

Brewerton TD, Reus VI. "Lithium carbonate and L-tryptophan in the treatment of bipolar and schizoaffective disorders." Am J Psychiatr. 1983;140:757-60.

Chouinard G, et al. "Tryptophan-nicotinamide, imipramine and their combination in depression: a controlled study." Acta Psychiatr Scand. 1979;59:395-414.

Coppen A, Wood K. "Tryptophan and depressive illness." Psychol Med. 1978;8:49-57.


S-Adenosyl-L-Methionine (SAM)

Carney MWP, et al. "The switch mechanism and the bipolar/unipolar dichotomy." Br J Psychiatr. l989;154:48-51.

Tolbert LC, et al. "Clinical correlations of one-carbon metabolism abnormalities." Prog Neuropsychopharmacol Biol Psychiatr. l988;12(4):491-502.

Carney MWP, et al. "Switch and S-adenosylmethionine." Ala J Med Sci. l988;25(3): 316-19.


Melatonin

Pacchierotti C, et al. "Melatonin in psychiatric disorders: a review on the melatonin involvement in psychiatry." Front Neuroendocrinol. 2001;22:18-32.

Nurnberger JI, et al. "Melatonin suppression by light in euthymic bipolar and unipolar patients." Arch Gen Psychiatry. June,2000;57:572-579.

Avery D, et al. "Guidelines for prescribing melatonin." Ann Med. 1998;30:122-130.

Kenedy SH. "Melatonin and cortisol 'switches' during mania, depression, and euthymia in a drug free bipolar patient." J Nerv Mental Dis. l989;l77(5):300-303.

Arendt J. "Melatonin: a new probe in psychiatric investigation?" Br J Psychiatry. 1989;155:585-590.

Mayeda A, Nurnberger JI. "Melatonin and circadian rhythms in bipolar mood disorder." Melatonin in Psychiatric and Neoplastic Disorders. Ch.5:105-123.


Serine

Fekkes D, et al. "Abnormal plasma levels of serine, methionine and taurine in transient, acute, polymorphic psychosis." Psychiatry Res. 1994;51:11-18.


Botanical References


Hypericum perforatum, Piper methysticum, Eleutherococcus senticosus, Avena sativa, Scutellaria laterifolia, Matricaria chamomilla, Lavender angustifolia

Mayers AG, et al. "Use of St. John's Wort (Hypericum perforatum l) in members of a depression self-help organisation: a 12-week open prospective pilot study using the HADS scale." Prim Care Psychiatry. 2003;9(1):15-20.

Mitchell WA. Plant Medicine. Preparatory Manuscript; Seattle, WA; 2000.

Tilgner S. Herbal Medicine-From the Heart of the Earth. Wise Acres Press, Inc.; Creswell, OR; 1999.

Ogletree RL, Rischer RG. Physician's and Pharmacist's Guide to the Top 10 Scientifically Proven Natural Products. Natural Source Digest; 2nd Ed. Brandon, MS; 1997.

Balch JF, et al. Prescription for Nutritional Healing, 2nd ed. Avery Publishing; NY, NY. 1997:168.

Chevallier A. The Encyclopedia of Medicinal Plants. DK Publishing; New York, NY; 1996.

Murray MT. The Healing Power of Herbs. 2nd Ed. Prima Publishing; Rocklin, CA; 1995.

Ellingwood F. American Materia Medica, Therapeutics and Pharmacognosy; Botanical Vol. II. Eclectic Medical Publications; Sandy, OR; 1994.

Felter HW. The Eclectic Materia Medica, Pharmacology and Therapeutics, Botanical Vol. 1. Eclectic Medical Publications; Sandy, OR; 1994.

Scalzo R. Naturopathic Handbook of Herbal Formulas. 3rd Ed. Kivaki Press; Durango, CO; 1994.

Ody P. The Complete Medicinal Herbal. Dorling Kindersley; New York, NY; 1993.

Stansbury JE. Botanical Medicines Acting on the Respiratory System. Preparatory Manuscript; Battleground, WA; 1992.

Stansbury JE. Pharmacognosy for the Herbal Practitioner. Preparatory Manuscript; Battleground, WA; 1992.

Thomas L. 10 Essential Herbs. Hohm Press; Prescott, AZ; 1992.

Weiss RF. Herbal Medicine. Beaconsfield Publishers LTD; Beaconsfield, England; 1991.

Hoffman D. The New Holistic Herbal. Element Inc; Rockport, MA; 1991.

Mabey R, et al. The New Age Herbalist. Collier Books, Macmillan Publishing Company; New York, NY; 1988. England;1988.

Tyler VE, et al. Pharmacognosy. 9th Ed. Lea & Febiger; Philadelphia, PA; 1988.

Wren RC. Potter's New Cyclopaedia of Botanical Drugs and Preparations. The C.W. Daniel Company Limited; Essex; 1988

Carr A, et al. Rodale's Illustrated Encyclopedia of Herbs. Rodale Press; Emmaus, PA; 1987.

Mowrey DB. The Scientific Validation of Herbal Medicine. Keats Publishing, Inc.; New Canaan, CT; 1986.

Beyer P. The Master Book of Herbalism. Phoenix Publishing; Custer, WA; 1984.

Goodenough J. Dr. Goodenough's Home Cures & Herbal Remedies. Avenel Books; New York, NY; 1982.

Millspaugh CF. American Medicinal Plants. Dover Publications, Inc.; New York, NY; 1974.

Grieve M. A Modern Herbal. Vol. I & II; Dover Publications, Inc.; New York, NY; 1971.


Schisandra chinensis

Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, 2d ed. New York: John Wiley & Sons. 1996,469-72.

Foster S, Chongxi Y. Herbal Emissaries: Bringing Chinese Herbs to the West. Rochester, VT: Healing Arts Press. 1992,146-52.

Shu HY. Oriental Materia Medica: A Concise Guide, Palos Verdes, CA: Oriental Healing Arts Press. 1986,624-5.


Homeopathy References


Morrison R.Desktop Guide to Keynotes and Confirmatory Symptoms.Hahnemann Clinic Publishing; Albany, CA; 1993.

Murphy R.Homeopathic Medical Repertory.Hahnemann Academy of North America; Pagosa Springs, CO; 1993.

Phatak SR. A Concise Repertory of Homoeopathic Medicines. B. Jain Publishers Pvt. Ltd.; New Delhi, India; 1992.

Kruzel T. The Homeopathic Emergency Guide.North Atlantic Books; Berkeley, CA; 1992.

Kent JT. Repertory of the Homeopathic Materia Medica.B. Jain Publishers (P) LTD; New Delhi, India; 1991.

Boericke W. Materia Medica with Repertory, 9th Ed..Boericke & Tafel, Inc.; Santa Rosa, CA; 1927.


Other Treatment References


Vanadium Chelation

French RJ, Jones PJ. "Role of vanadium in nutrition: metabolism, essentiality and dietary considerations." Life Sci. 1993;52(4):339-346.

Naylor GJ. "Vanadium and manic-depressive psychoses." Nutr Health. 1984;3(1-2):79-85.

Kay DS, et al. "The therapeutic effect of ascorbic acid and EDTA in mani-c-depressive psychosis: double-blind comparisons with standard treatments." Psychol Med. 1984;14(3):533-38.

Naylor GJ, Smith AHW. "Vanadium: a possible aetiological factor in manic-depressive illness." Psychol Med. 1981;11:249-56.

Witkowska D, Brzezinski J. "Alteration of brain noradrenalin, dopamine and 5-hydroxy-tryptamins levels during vanadium poisoning." Pol J Pharacol Pharm. 1979;31:393-98.


Iron Chelation

FeifelD, Young CW. "Iron overload among a psychiatric outpatient population." J Clin Psychiatry. 1997;58(2):74-78.


Replace Mercury Amalgam Fillings

Siblerud RL, et al. "Psychometric evidence that dental amalgam mercury may be an etiological factor in manic depression." J Orthomol Med. 1998;13(1):31-41.


Stop Smoking

Gonzalez PA, et al. "Tobacco smoking and bipolar disorder." J Clin Psychiatr. May,1998;59(5):225-8.


Obesity

Simon GE, et al. "Association between obesity and psychiatric disorders in the US adult population." Arch Gen Psychiatry. 2006;63(7):824-30.

Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).