Below are supplemental abstracts and references of research that support the conclusions on the treatment for Insomnia

. Diet and Nutrition References


Food Allergies and Elimination Diet

Hedges HH. "The elimination diet as a diagnostic tool." AFP J. November,1992;46(5):77S-85S.

Savilahti E. "Diagnostic criteria for food allergy with predominantly intestinal symptoms." J Pediatric Gastroenterol Nutr. 1992;14:108-112.

Kahn A, et al. "Milk intolerance in children with persistent sleeplessness: a perspective double-blind cross-over study." Pediatrics. October,1989;84(4):595-603.

Speer F. "The allergic tension-fatigue syndrome." Pediatr Clin N Am. November,1954:1:1029-1037.


Food Additives

Rowe KS, Briggs DR. "Food additives and behavior." Med J Austral. November21,1994;161:581-582.


Caffeine

Wright KP, et al. "Caffeine and light Effects on nighttime melatonin and temperature levels in sleep-deprived humans," Brain Res. 1997;747:78-84.

Brown SL, et al. "Occult caffeine as a source of sleep problems in an older population." J Am Geriatric Soc. 1995;43:860-864.

Tarnopolsky MA. "Caffeine and endurance performance." Sports Med. 1994;18(2):109-125.

Snel J. "Coffee and caffeine: sleep and wakefulness." Caffeine, Coffee and Health, Raven Press, New York. 1993;225-290.

Chou T. "Wake up and smell the coffee: caffeine, coffee and the medical consequences." West J Med. November 1992;157(5):544-553.

Tondo L, et al. "Course of seasonal bipolar disorder influenced by caffeine." J Affective Disorders. 1991;22:249-251.

Zaslove MO, et al. "Effect of caffeine intake on psychotic in-patients", Br J Psychiatry. 1991;159:565-567.

Regestein QR. "Pathologic sleepiness induced by caffeine." Am J Med. November,1989;87:586-588.

Shirlow MJ, Mathers CD. "A study of caffeine consumption and symptoms: indigestion, palpitations, tremor, headache and insomnia." Intl J Epidemiol. 1985;14(2):239-248.

Rapoport J. "Caffeine and behavior: relation to psychopathology and underlying mechanisms." Psychopharmacol Bull. 1984;20(3):426-430.

Karacan I, et al. "Dose-related sleep disturbances induced by coffee and caffeine." Clin Pharmacol Ther. 1976;20(6):682-689.

Brezinova V, et al. "Two types of insomnia: too much waking or not enough sleep." Br J Pyschiat. 1975;126:439-445.


Vitamin and Mineral References


Vitamin B1

Wilkinson TJ, et al. "The response to treatment of subclinical thiamine deficiency in the elderly." Am J Clin Nutr. 1997;66:925-928.

Smidt LJ, et al. "Influence of thiamin supplementation on the health and general well being of an elderly population with marginal thiamin deficiency." J Gerontol. 1991;46(1):M16-M22.

Williams RD, et al. "Induced thiamine (vitamin V1) deficiency in man: relation of depletion of thiamine to development of biochemical defect and of polyneuropathy." Arch Intern Med. 1943;71:38-53.


Vitamin B12

Tomoda A, et al. "Circadian rhythm abnormalities in adrenoleukodystrophy and methyl B12 treatment." Brain Dev. 1995;17:428-431.

Itoh H, et al. "Effects of vitamin B12 and bright light on circadian rhythms." Jap J Psychiatry Neurol. 1994;48(2):502-505.

Okawa M, et al. "Favorable effects of combined treatment with vitamin B12 and bright light For sleep-wake rhythm disorders." Sleep-Wakefulness; 1993, Wiley Eastern, Ltd.;71-77.

Honma K, et al. "Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock." Experientia. 1992;48:716-720.

Okawa M, et al. "Vitamin B12 treatment for sleep-wake rhythm disorders." Jap J Psychiatry Neurobiol. 1991;45(1):165-166.

Bell IR. "Vitamin B12 and folate in acute geropsychiatric in-patients." Nutr Report. January,1991;9(1):1,8.

Ohta T, et al. "Treatment of persistent sleep-wake schedule disorders in adolescents and vitamin B12." Jap J Psychiatry Neurol. 1991;45(1):167-168.

Okawa M, et al. "Vitamin B12 treatment for sleep-wake rhythm disorders." Sleep. 1990;13(1):15-23.


Magnesium

Hornyak M, et al. "Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study." Sleep. 1998;21(5):501-505.

Friedman B. "Magnesium for restless sleepers." Cortlandt Forum. February,1992;121/48-10.

Cox IM, et al. "Red blood cell magnesium and chronic fatigue syndrome." Lancet. March30,1991;337:757-760.

Hofle KH. "Magnesium in psychotherapy." Magnesium Res. 1988;1:99,10th Hohenheim Magnesium Symposium.


Supplement References


Melatonin

Andrade C, et al. "Melatonin in medically ill patients with insomnia: a double-blind, placebo-controlled study." Clin Psychiatry. January,2001;62(1):41-45.

"Melatonin use in older patients." Fam Prac News. October1,2000:16.

Bursztajn HJ. "Melatonin therapy: from benzodiazepine-dependent insomnia to authenticity and autonomy." Arch Intern Med. November8,1999;159:2393-2395.

Nowak JZ, Zawilska JB. "Melatonin and its physiological and therapeutic properties." Pharmacy World Sci. 1998;20(1):18-27.

Avery D, et al. "Guidelines for prescribing melatonin." Annal Med. 1998;30:122-130.

Sack RL, et al. "Use of melatonin for sleep and circadian rhythm disorders." Annal Med. 1998;30:115-121.

McArthur AJ, Budden SS. "Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment." Dev Med Child Neurol. 1998;40:186-192.

Okawa M, et al. "Melatonin treatment for circadian rhythm sleep disorders." Jap Soc Sleep Res. 1998:259-260.

Jan JE, et al. "Melatonin treatment of chronic sleep disorders." J Child Neurol. 1998;13(2):98.

Garfinkel D, Berner YN. "Antioxidants and aging: is melatonin a possible, practical new hope?" Nutr. 1998;14(9):712-713.

Cupp MJ. "Melatonin." Am Fam Phys. October1,1997;1421-1425.

Haimov I, et al. "Melatonin - a possible link between sleep and the immune system." Israel J Med Sci. 1997;33(4):246-250.

Saletu B. "Melatonin - a natural sleeping pill?" Wien Klin Wochenschr. 1997;109/18:714-721.

Mishima K, et al. "Hypnotic and hypothermic action of daytime-administered melatonin." Psychopharmacol. 1997;133:168-171.

deVries MW. "Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression." J Nervous Mental Dis. 1997;185(3):201-202.

Palm L, et al. "Long-term melatonin treatment in blind children and young adults with circadian sleep- wake disturbances." Dev Med Child Neurol. 1997;39:319-325.

Reid K, et al. "Day-time melatonin administration: effects on core temperature and sleep onset latency." J Sleep Res. 1996;5:150-154.

Zhdanova IV, et al. "Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans." Sleep. 1996;19(5):423-431.

Comperatore CA, et al. "Melatonin efficacy in aviation missions requiring rapid deployment and night operations." Aviation Space Envir Med. June,1996;67(6):520-524.

Middleton BA, et al. "Melatonin and fragmented sleep patterns." Lancet. August24,1996;348:551.

Singer C, et al. "Melatonin and sleep in the elderly." J Am Geriatr Soc. September,1996;44(9):S1(#A1).

Attenburrow MEJ, et al. "Case-control study of evening melatonin concentration in primary insomnia." Br Med J. May 18,1996;312:1263-1264.

Deacon S, Arendt J. "Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans." Brain Res. 1995;688:77-85.

Wurtman RJ, Zhdanova I. "Improvement of sleep quality by melatonin." Lancet. December2,1995;346:1491.

Zhdanova IV, et al. "Sleep-inducing effects of low doses of melatonin ingested in the evening." Clin Pharmacol Ther. May,1995;57(5):552-558.

Webb SM, Puig-Domingo M. "Role of melatonin in health and disease." Clin Endocrinol. 1995;42:221-234.

Hagan RM, Oakley NR. "Melatonin comes of age." TIPS. March,1995;16:81-83.

Nave R, et al. "Melatonin improves evening napping." European J Pharmacol. 1995;275:213-216.

Brown GM. "Melatonin in psychiatric and sleep disorders: therapeutic implications." CNS Drugs. 1995;3(3):209-226.

Jan JE, Espezel H. "Melatonin treatment of chronic sleep disorders." Dev Med Child Neurol. 1995;37:279-280.

Garfinkel D, et al. "Improvement of sleep quality in elderly people by controlled-release melatonin." Lancet. August 26,1995;346:541-544.

"Melatonin: researchers say hormone markely improves sleep, behavior of developmentally disabled children." Autism Res Rev. 1994;8(3):1-2.

Jan JE, et al. "The treatment of sleep disorders with melatonin." Dev Med Child Neurol. 1994;36:97-107.

Haimov I, et al. "Sleep disorders and melatonin rhythms in elderly people." Br Med J. 1994;309:167.

Dawson D, et al. "Melatonin and sleep in humans." J Pineal Res. 1993;15:1-12.

Nickelsen T, et al. "Influence of subchronic intake of melatonin at various times of day on fatigue and hormonal levels: a placebo-controlled, double-blind trial." J Pineal Res. l989;6:325-334.


Tryptophan

Voderholzer U, et al. "Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in Healthy Subjects." Neuropsychopharmacol. 1998;18:112-124.

Heine W, et al. "The significance of tryptophan in human nutrition." Amino Acids. 1995;9:191-205.

Sandyk R, "L-tryptophan in neuropsychiatric disorders: a review." Intl J Neurosci. 1992;67:127-144.

Van Der Mast RC, et al. "Is postoperative delirium related to reduced plasma tryptophan?" Lancet. October5,1991;338:851-852.

Newsholme EA, et al. "Physical and mental fatigue: do changes in plasma amino acids play a role." Biochem Soc Transactions. 1991;19:358-362.

Hajak G, et al. "The influence of intravenous L-tryptophan on plasma melatonin and sleep in men." Pharmacopsychiat. 1991;24:17-20.

Shapira IL. "Use of L-tryptophan." J Am Dent Assoc. June,l989;ll8:682.

Lahmeyer HW. "Tryptophan for insomnia." JAMA. November17,1989;262(19):2748.

Schneider-Helmert D, Spinweber CL. "Evaluation of L-tryptophan for treatment of insomnia: a review." Psychopharmacol. 1986;89:1-7.

Spinweber CL, et al. "L-tryptophan: effects on daytime sleep latency and the waking EEG." Electroencephalogr Clin Neurophysiol. 1983;55:652-661.

Yogman MW, Zeisel SH. "Diet and sleep patterns in newborn infants." N Engl J Med. November,1983;309(19):1147-1149.

Hartmann E. "L-tryptophan: a Possible natural hypnotic substance." JAMA. December23-30,1974;230(12):1680-1681.


DHEA

Brolinson PG, Rice EL. "Is DHEA useful to help prevent and treat certain illnesses?" Fam Prac News. March1,1998;17.

Friess E, et al. "DHEA administration increases rapid eye movement sleep and EEG power and sigma frequency range." Am J Physiol. 1995;268:E107-E113.


Essential Fatty Acids

Yehuda S, et al. "Essential fatty acids and sleep: mini-review and hypothesis." Med Hypoth. 1998;50:139-145.

Pullman-Mooar S, et al. "Alteration of cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma - linolenic acid." Arth Rheum. October,1990;33(10):1526-1532.


Botanical References


St. John's Wort, Kava Kava, Valerian and Melatonin

"Herbal medications in neuropsychiatry." Women's Health in Primary Care. December,2000;3(12):851-853.

Wheatley D. "Hypericum in seasonal affective disorder (SAD)." Curr Med Res Opinion. 1999;15(1):33-37.

Heiligenstein E. Guenther G. "Over-the-counter psychotropics: a review of melatonin, St. John's wort, valerian, and kava-kava," J Am Coll Health. May,1998;46:271-276.

Wong AHC, et al. "Herbal remedies in psychiatric practice." Arch Gen Psychiatry. November,1998;55:1033-1044.


Kava Kava

Fugh-Berman A, Cott JM. "Dietary supplements and natural products as psychotherapeutic agents." Psychosom Med. 1999;61:712-728.

Sherman C. "Herbal anxiolytics have novel mechanisms." Fam Prac News. July15,1998:30.


Valerian

Kirn TF. "Group rates efficacy of herbs." Fam Prac News. April15,2004;34(8):1. 26.

Fugh-Berman A. "Clinical trials of herbs," Prim Care. December,1997;24(4):889-903.

Lindahl O, Lindwall L. "Double blind study of a valerian preparation." Pharmacol Biochem Behav. 1989;32:1065-1066.

Leathwood PD, Chauffard F. "Aqueous extract of valerian reduces latency to fall asleep in man." Planta Medica. 1985;144-148.

Balderer G, Borbely AA. "Effect of valerian on human sleep." Psychopharmacol. 1985;87:406-409.


Homeopathy References


Morrison R.Desktop Guide to Keynotes and Confirmatory Symptoms.Hahnemann Clinic Publishing; Albany, CA; 1993.

Murphy R.Homeopathic Medical Repertory.Hahnemann Academy of North America; Pagosa Springs, CO; 1993.

Phatak SR. A Concise Repertory of Homoeopathic Medicines. B. Jain Publishers Pvt. Ltd.; New Delhi, India; 1992.

Kruzel T. The Homeopathic Emergency Guide.North Atlantic Books; Berkeley, CA; 1992.

Kent JT. Repertory of the Homeopathic Materia Medica.B. Jain Publishers (P) LTD; New Delhi, India; 1991.

Boericke W. Materia Medica with Repertory, 9th Ed..Boericke & Tafel, Inc.; Santa Rosa, CA; 1927.


Other Treatment References


Exercise

Youngstedt SD. "Does exercise truly enhance sleep." Phys Sportsmed. October,1997;25(10):72-82.

King AC, et al. "Moderate-intensity exercise and self-rated quality of sleep in older adults: a randomized controlled trial." JAMA. January1,1997;277(1):32-37.

Singh NA, et al. "Sleep, sleep deprivation, and daytime activities: a randomized controlled trial of the effect of exercise on sleep." Sleep. 1997;20(2):95-101.

Driver HS, Taylor SR. "Sleep disturbances and exercise." Sports Med. January,1996;21(1):1-6.

Kubitz KA, et al. "The effects of acute and chronic exercise on sleep: a meta-analytic review." Sports Med. 1996;21(4):277-291.

Stamford B. "The role of exercise in fighting depression." Phys Sports Med. December,1995;23(12):79-80.

Carlucci D, et al. "Exercise: not just for the healthy." Phys Sports Med. July,1991;19(7):46-52.

Chambers MJ. "Exercise: a prescription for a good night's sleep." Phys Sports Med. August,1991;19(8):107-114.


Light Therapy

Hayakawa T, et al. "Trials of bright light exposure and melatonin administration in a patient with non-24 sleep-wake syndrome." Jap Soc Sleep Res. 1998:261-262.

Lam RW, et al. "Light therapy for depressive disorders: indications and efficacy." Mood Disorders, Systematic Medication Management. 1997;25:215-234.

Zal HM. "Seasonal affective disorder: how to lighten the burden of 'winter depression'." Consultant. March,1997;641-649.

Partonen T, et al. "Effects of bright light on sleepiness, melatonin, and 25-hydroxyvitamin D3 in winter seasonal affective disorder." Biol Psychiatry. 1996;39:865-872.

Mishima K, et al. "Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia." ACTA Psychiatr Scand. 1994;89:1-7.

Partonen T, Partinen M. "Light treatment for seasonal affective disorder: theoretical considerations and clinical applications." ACTA Psychiatrica Scand. 1994;Suppl. 377:41-45.

Costa G, et al. "Effect of bright light on tolerance to night work." Scand J Work Envir Health. 1993;19:414-420.

Satlin A, et al. "Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease." Am J Psychiatry. August,1992;149:8:1028-1032.

Castor D, et al. "Effect of sunlight on sleep patterns of the elderly." J Am Acad Phys Assistants. June,1991;4(4):321-326.

McIntyre IM, et al. "Treatment of seasonal affective dDisorder with light: preliminary Australian experience." Australian New Z J Psychiatry. 1989;23:369-372.


Relaxation Techniques

Edinger JD, et al. "Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial." JAMA. April11,2001;285(14):1856-1864.

McDowell JA, et al. "A nonpharmacologic sleep protocol for hospitalized older patients." J Am Geriatric Soc. June,1998;46(6):700-705.

"Integration of behavioral and relaxation approaches into the treatment of chronic pain and Insomnia." JAMA. July24/31,1996;276(4):313-318.


Organic Solvents

Lindelof B, et al. "Sleep disturbances and exposure to organic solvents." Arch Envir Health. March/April,1992;47(2):104-106.


Lead Chelation

"Lead poisoning in bridge demolition workers - Georgia, 1992." Morbid Mortal Weekly Rep. May28,1993;42(20):388-390.

Hurley D. "Adults lead levels track: NIOSH says 5% of employers tested For lead." Med Trib. October22,1992;7.

Balestra DJ, et al. "Adult chronic lead toxication: a clinical review." Arch Int Med. September,1991;151:1718-1720.

"Lead poisoning among battery reclamation workers - Alabama 1991." Morbid Mortal Weekly Rep. May1,1992;41(17);301-304.


Smoking

Phillips BA, Danner FJ. "Cigarette smoking and sleep disturbance." Arch Int Med. 1995;155:734-737.

Mountifield JA. "Restless leg syndrome relieved by cessation of smoking." Can Med Assoc J. September1,1985;133:426-427.

Copyright 1998 - 2008 by L. Vicky Crouse, ND and James S. Reiley, ND. All rights reserved (ISSN 1527-0661).